According to healthcare experts, there are several situations when it may be appropriate to wear a knee braces. If you are sitting down for long periods or only walking short distances at home, you should take off the knee brace as it is probably not necessary to have it on. However, those with a degenerative condition, such as osteoarthritis of the knee, may find it helpful to wear a knee support braces when you are more active, playing a sport, or on your feet for long periods. Additionally, it is a good idea to wear your knee brace when you are going to be on your feet for long periods or performing simple tasks that may irritate or destabilize your knee, such as bending or twisting. The best knee brace for bone on bone conditions may also be helpful for any activity where you need support with your stability.